SLIP and SLIDE

Rapid multiple hypothesis testing correction (SLIDE) and power estimation (SLIP)
SLIDE

SLIDE (Sliding-window method for Locally Inter-correlated markers with asymptotic Distribution Errors corrected) is a multivariate normal distribution (MVN)-based multiple hypothesis testing correction method. SLIDE shows a near identical accuracy to the gold standard, the permutation test, and is much faster.

SLIP

SLIP (Sliding-window method for Locally Inter-correlated markers for Power estimation) is a multivariate normal distribution (MVN)-based power estimation method. SLIP shows a near identical accuracy to the standard simulation procedure for power, and is much faster.

Download

SLIDE (Linux compatible, 32 bit) slide.1.0.4.tar.gz

SLIDE (Linux compatible, Intel64) slide.1.0.4.intel64.tar.gz

SLIDE (Mac OS, 32 bit) slide.1.0.4 (Mac OS, 32bit)

SLIDE (Mac OS, Intel64) slide.1.0.4 (Mac OS, 64bit)

SLIP (Linux compatible, 32 bit) slip.1.0.1.tar.gz

Version/bug info

SLIDE

v1.0.4 (2010-06-11) Mac OS version added
v1.0.4 (2009-10-29) bug in using option -QG is now fixed (Thanks to Dr. Sungeun Kim)
v1.0.3 (2009-09-16) Intel64 compiled version is now available for dealing with large file (>2Gb) (Thanks to Dr. Roman Pahl)
v1.0.2 (2009-05-21) bug in format converter fixed (Thanks to Dr. Lisa Martin for reporting the bug.)
v1.0.1 (2009-03-16) format converter PED->SLIDE included
v1.0.0 (2009-01-28) released

SLIP

v1.0.1 (2009-03-11) format converter SLIP->SLIDE included for estimating per-marker threshold
v1.0.0 (2009-03-10) released

Publication

Buhm Han, Hyun Min Kang, and Eleazar Eskin (2009) Rapid and accurate multiple testing correction and power estimation for millions of correlated markers. PLoS Genet 5(4): e1000456. doi:10.1371/journal.pgen.1000456

Contact

Buhm Han - buhan (AT) cs-ucsd-edu
Eleazar Eskin - eeskin (AT) cs-ucla-edu (Please replace dashes ‘-’ with dots ‘.’)

License information

Copyright (c) 2009 ZarLab. The softwares are provided “AS IS”, without warranty of any kind, express or implied, including but not limited to the warranties of merchantability, fitness for a particular purpose and noninfringement. In no event shall the authors or copyright holders be liable for any claim, damages or other liability, whether in an action of contract, tort or otherwise, arising from, out of or in connection with the software or the use or other dealings in the software.